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KMID : 1189420190320030023
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Journal of Korean Oriental Medical Ophthalmology & Otolaryngology & Dermatology
2019 Volume.32 No. 3 p.23 ~ p.36
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A Clinical Study for the Efficacy and Safety of Functional Cosmetics Containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans in Patients with Dry Skin due to Mild Atopic Dermatitis
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Park Hye-Su
Kim Tae-Jun
Park Shin-Yong
Kim Hee-Taek
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Abstract
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Objectives : The purpose of this study is to confirm the efficacy and safety of “Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans” on dry skin due to mild atopic dermatitis.
Methods : A total of 24 patients who visited Semyung Oriental Medical Center from November 1st, 2018 to December 20th, 2018 were included in the study. In this study, the patients were treated with Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans. For 4 weeks of gross examination, instrumental assessment were made before and after the study to evaluate how well the products for treatment group in recovering the dry skin barriers by mild atopic dermatitis.
Results : 1. In the primary endpoint, Skin Hydration showed a statistically significant increase in treatment group in baseline, 2 weeks and 4 weeks. 2. In the primary endpoint, Transepidermal Water Loss(TEWL) showed a statistically significant decrease in treatment group between Baseline and 4 weeks. 3. In the secondary endpoint, Skin pH showed a statistically significant decrease in treatment group between baseline and 4 weeks. 4. To evaluate the safety of the products for the human body, Adverse events, SCORAD Index Assessment were conducted; There were no severe adverse events during this study. And SCORAD Index showed a statistically significant decrease in treatment group in baseline, 2 weeks and 4 weeks. Therefore, it is suggested that products, if used for certain period, should be safe for the human body.
Conclusions : According to the above experiments, it is suggested that “Functional cosmetics containing peptide Scolopendrasin-I isolated from the Scolopendra subspinipes mutilans” should be effective for dry skin due to mild atopic dermatitis.
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KEYWORD
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Atopic dermatitis, Scolopendrasin-I, Scolopendra subspinipes mutilans, Functional cosmetics, Moisturizing
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